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Needle-free injection system is an innovative way to introduce medication into a patient’s body. Unlike the conventional needle injection system, needle-free injection do not penetrate through the skin. Needle-free injection system is steadily emerging as an efficient way to administer the medication with better patient compliance. There are various advantages offered by needle-free injection system. This system offers efficiency in administration of medication with better patient compliance especially for children (vaccination), geriatric patients (palliative and other care), and patients with chronic diseases such as diabetes, GI tract disease, and multiple sclerosis who need daily injection administration. Self-medication becomes convenient with needle-free injection due to increased confidence amongst user for self-medication and therefore it offers better treatment adherence and improved quality of life.